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FAT ATTACK MARCH 05

Excess Pounds By Dropping a Load

A Glycemic Load

            Bodybuilders fret and worry about every last ounce of fat as they prepare for a contest. For those grueling eight to 12 weeks, calories are counted and carbohydrates are cut in the effort to reach an extremely low body fat. Once the stage lights dim, the temptation for an ice cream sundae may become overwhelming and pizza lures erstwhile athletes back into the comfortable zone of complacency with its siren song of sauce and toppings.
            With the exception of a rare few, most athletes, bodybuilders and celebrities relax their standards, gaining several pounds during their off-season. After the first few weeks to months, the added girth becomes uncomfortable and unpleasant by their standards, causing them to actively begin managing their weight again through a moderate diet plan.
            Everyone, even the larger-than-life celebrities created by sports and the media, worries about gaining excess weight. In addition to the pressure of being in the spotlight and the career need to look good, every person- public and private- has to consider the impact of extra fat on future health. Longevity and health are taken for granted by teenagers and young adults, but once issues like home ownership and teacher conferences become more important than music videos and all-night raves, it's time to pay attention to health maintenance. Suddenly, the day will come when headlines about heart health and cancer prevention are as eye-catching as Ronnie Coleman's biceps workout or a Halo 2 review.

            Why Low-Fat Diets Don't Succeed
The basics of losing weight are simple; take in fewer calories than you burn.1 For athletes, it's more important to lose fat than weight, but the essentials are very similar. For years, dieticians had nice, long tables they could proudly display showing the calorie content of every food product. To add credence to their technique, they often teamed up with a health organization, like the American Heart Association, claiming their method would improve health and prolong the life span.2 The doctrine for years was to eat a low-fat diet, as the evil saturated fats that dripped from T-bone steaks and cheeseburgers would clog arteries and deposit squarely, (actually roundly, unless you are a yellow sponge), on your hips.
            Yet, as we have learned thanks to pioneers like Barry Sears and Robert Atkins, the traditional low-fat diet is no safer than other alternatives. In fact, low-carb/high-protein diets like the Zone and South Beach have been shown to be more effective in the short term and possibly even healthier alternatives than the carbohydrate- dominant, low-fat diets touted by dieticians and cardiologists.3-6
            In the search for an explanation for the relative failure of low-fat diets in facilitating weight loss and improving health, scientists have identified a likely culprit: refined carbohydrates.7 As the less well regarded high-protein diets have explained, to maximally promote fat loss, the release of insulin must be controlled.8 Insulin is a hormone produced by the pancreas, a gland located in the belly. When the body detects a rise in blood sugar, insulin is released and travels through the bloodstream. Insulin interacts with receptors on most cells and tissues in the body, the brain being the primary exception, starting a signal that drives sugar from the blood into active tissues, such as muscle.9,10
In addition to its action on blood sugar, insulin affects fat metabolism. When insulin is elevated, or if it remains elevated above normal fasting levels, fat cells are encouraged to store fat and are inhibited from releasing any stored fat.10,11 Other negative changes are also associated with persistently high insulin levels, including high triglycerides, low HDL (good cholesterol), high blood pressure, central (abdominal) obesity, increased risk of blood clots and chronic inflammation.10,12 This collection of problems is termed the metabolic syndrome and is being recognized as one of the greatest health threats facing the nation's health care system.13
           
            The Insulin Connection
Obviously, there are notable reasons to control insulin. Most people who are aware of insulin have a rough idea of how to manage it- by cutting down sugar in the diet. This basic level of understanding is an excellent start. Refined carbohydrates, whether they come from candy, bread, potatoes or pastries, flood the system with sugar and a vigorous insulin response is required to deal with the sugar tsunami.14,15 The insulin peak can remain elevated, even after the sugar levels have fallen back to normal. This accounts for the sudden lethargy that is experienced after a sugar rush, sometimes called an insulin dump.
 In some people, often sedentary individuals who tend to be overweight, the body becomes resistant to insulin's signal and greater amounts of insulin are released for longer periods.13,15 The persistence of elevated insulin is a condition that precedes the metabolic syndrome. Some researchers believe insulin resistance is not just a component of the metabolic syndrome, but is actually the cause of the condition.10,12,16
            Dieticians recognize that the body does not respond to all carbohydrates in the same fashion. Simple sugars elicit a vigorous insulin response, but others induce a more mild insulin response. The insulin response appears to be related to the rate at which sugars from food are digested and absorbed into the bloodstream. Foods that quickly release sugar into the bloodstream cause a fast and large peak in insulin levels; such foods rate high on a scale called the glycemic index.14,15 Thus, sugary foods like kids' cereals, white bread and many sports drinks are called "high glycemic index foods." Carbohydrates that break down slowly, like whole grains and beans, release sugar into the system slowly and stimulate a mild insulin response; these are "low glycemic index foods."
Beyond the concept of the glycemic index is a calculation called the glycemic load. The glycemic load of a diet is calculated by multiplying the glycemic index of a diet by the number of carbohydrates (in grams). The practice behind many of today's popular diets is to lower weight and improve health by decreasing the amount of insulin released. Researchers recently published a study comparing a low glycemic load diet to a traditional low-fat diet relying upon breads and other high glycemic index foods on weight loss, metabolism and heart disease risk factors.17

            New Research
In this study, two groups of overweight individuals were subjected to baseline measurements and then given prepared meals designed to induce weight loss by providing only 60 percent of calculated maintenance calories. The subjects were required to show up every day to eat the prepared lunch under the observation of the researchers; then they were provided with a prepared snack, dinner and breakfast to eat off-site with instructions not to eat any outside foods. After subjects reached a target weight loss of 10 percent of initial bodyweight, they were re-measured and comparisons were made between the two groups.
            The first measure of note was the effect of the different diets on blood sugar and insulin. As intended, after eating the prepared meals, blood sugar and insulin was twice as high in the group following the traditional low-fat diet. While the low glycemic load subjects reached target weight quicker, both groups took on average slightly over two months to lose 10 percent of their initial bodyweight. Neither group demonstrated an advantage in maintaining or developing lean mass during weight loss, but this is not surprising, as exercise was not part of the weight loss program.18
            On the surface, it would appear there's no added benefit to controlling glycemic load, other than slightly quicker results. Bear in mind, these groups consisted of people who were not athletes, let alone bodybuilders. However, when examining the effect of the two diets through blood analysis and metabolic studies, the potential health benefits of lowering the glycemic load of the diet become evident. Perhaps, it might be more forceful to say the potential health risks of the traditional low-fat diet are exposed.
            Resting energy expenditure is a term used to describe the basal metabolic rate, or how many calories are burned at rest. Weight loss generally has a negative effect on resting energy expenditure, meaning it becomes more difficult to lose more weight because the body is trying to protect itself from starvation by burning fewer calories at rest. Though both groups demonstrated a drop in resting energy expenditure, the degree of reduction was twice as great for the traditional low-fat diet group (176 vs. 96 calories per day). This means the low-fat group burned fewer calories every day, increasing the likelihood of regaining weight and making it more difficult to maintain weight loss. Eighty calories per day does not sound like much, but it's the caloric equivalent of walking one mile. All else being equal, the low glycemic load diet would allow for the loss of an additional eight pounds per year, every year.
Avoiding wild swings in insulin and blood sugar also seem to help control hunger, as subjects from the low glycemic load group reported being less hungry.

            Important Discoveries
Blood analysis revealed some very important discoveries that could impact individual health and the health care system in general. As discussed earlier, insulin resistance is one of the early signs preceding the onset of the metabolic syndrome. Using a scale that measures insulin resistance, it was shown that while the low-fat group improved significantly, the degree of improvement was two times higher in the low glycemic load group.
            As would be expected using the metabolic syndrome model, as insulin resistance decreased, improvements were seen in nearly all the associated signs and symptoms. Serum triglycerides, fats that float in the bloodstream affecting the risk of vascular disease, were significantly lower in the low glycemic load group. While cholesterol values were not significantly different between the two groups, a dramatic effect was noted on the state of inflammation. Inflammation in the vascular system is believed to be the initiating event in blood clots that lead to strokes and heart attacks.19
Only recently has the importance of lowering vascular inflammation been recognized. This inflammation is measured by levels of a marker called C-reactive protein. In the low glycemic load group, C-reactive protein decreased by 50 percent, while it remained unchanged in the low-fat group. This revelation alone is sufficient reason to recommend lowering the glycemic load of the diet. Lastly, blood pressure was reduced to a greater extent in the low glycemic group, though the change was not significant. This may be a factor of the relatively few subjects in the study.
            It is amazing that the dogma of the established "experts" is constantly failing the scrutiny and challenge of close examination; yet, the dietary practices of bodybuilders are standing up to objective criticism by scientists. Despite the growing body of evidence supporting the experiences and recommendations that have been gained over the decades by dedicated and disciplined athletes, the media and many regulatory agencies continue to dispute the efficacy of the bodybuilding lifestyle.4,5 Whether this is due to professional pride, political influence or a media agenda, it is unfortunate. The public has been conditioned to scoff at the minority that considers physical development to be part of a well balanced life and suffers because it is being misled about issues that impact everyone at both an individual and societal level.20 As this study clearly shows, the old guard is not infallible and it is time to embrace new ideas. 

References 

  1. Finer N. Low-calorie diets and sustained weight loss. Obes Res, 2001 Nov;9 Suppl 4:290S-294S.
  2. Bunyard LB, Dennis KE, et al. Dietary intake and changes in lipoprotein lipids in obese, postmenopausal women placed on an American Heart Association Step 1 diet. J Am Diet Assoc, 2002 Jan;102(1):52-7.
  3. Yancy WS, Olsen MK, et al. A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia: a randomized, controlled trial. Ann Intern Med, 2004 May 18;140(10):768-77.
  4. Astrup A, Meinert Larsen T, et al. Atkins and other low-carbohydrate diets: hoax or an effective tool for weight loss? Lancet, 2004 Sep 4;364(9437):897-9.
  5. Acheson KJ. Carbohydrate and weight control: where do we stand? Curr Opin Clin Nutr Metab, Care 2004 Jul;7(4):485-92.
  6. Foster GD, Wyatt HR, et al. A randomized trial of a low-carbohydrate diet for obesity. N Engl J Med, 2003 May 22;348(21):2082-90.
  7. Schulze MB, Manson JE, et al. Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women. JAMA, 2004 Aug 25;292(8):927-34.
  8. McLaughlin T, Abbasi F, et al. Relationship between insulin resistance, weight loss, and coronary heart disease risk in healthy, obese women. Metabolism, 2001 Jul;50(7):795-800.
  9. Rosenfeld L. Insulin: discovery and controversy. Clin Chem, 2002 Dec;48(12):2270-88.
  10. Ferrannini E, Galvan AQ, et al. Insulin: new roles for an ancient hormone. Eur J Clin Invest ,1999 Oct;29(10):842-52.
  11. Jacob S, Hauer B, et al. Lipolysis in skeletal muscle is rapidly regulated by low physiological doses of insulin. Diabetologia, 1999 Oct;42(10):1171-4.
  12. Deskalopolou SS, Mikhailidis DP, et al. Prevention and treatment of the metabolic syndrome. Angiology2004 Nov-Dec;55(6):589-612.
  13. Unger RH. Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology, 2003 Dec;144(12):5159-65.
  14. Morris KL, Zemel MB. Glycemic index, cardiovascular disease, and obesity. Nutr Rev, 1999 Sep;57(9 Pt 1):273-6.
  15. Pewlak DB, Ebbeling CB, et al. Should obese patients be counseled to follow a low-glycemic index diet? Yes.Obes Rev, 2002 Nov;3(4):235-43.
  16. Harris NS, Winter WE. The chemical pathology of insulin resistance and the metabolic syndrome. Med Lab Obs, 2004 Oct;36(10):20-25.
  17. Pereira MA, Swain J, et al. Effects of a low-glycemic load diet on resting energy expenditure and heart disease risk factors during weight loss. JAMA, 2004 Nov 24;292(20):2482-90.
  18. Tsai AC, Sandretto A, et al. Dieting is more effective in reducing weight but exercise is more effective in reducing fat during the early phase of a weight-reducing program in healthy humans. J Nutr Biochem, 2003 Sep;14(9):541-9.
  19. Kaplan RC, Frishman WH. Systemic inflammation as a cardiovascular disease risk factor and as a potential target for drug therapy. Heart Dis, 2001 Sep-Oct;3(5):326-32.
  20. Kruger J, Galuska DA, et al. Attempting to lose weight: specific practices among U.S. adults. Am J Prev Med,2004 Jun;26(5):402-6.

FAT ATTACK NOV 22

Fat Attack
By Dan Gwartney, MD
Growth Hormone Secretagogues
A Tale of Two Pities

Growth hormone (GH) has long been considered the hormonal Fountain of Youth.1 In addition to aiding in tissue repair and bioenergetics, GH also has potent anabolic and lipolytic properties that are of particular interest to bodybuilders and athletes.2

A Widening Interest

GH use by healthy adults is limited due to legal restrictions and cost. Physicians are increasingly being prosecuted or professionally ostracized for treating age-related decline of GH. Prescribing GH to a healthy, young adult for the purposes of improving appearance or athletic performance is prohibited, subjecting physicians who violate this edict to a loss of his/her medical license and potential imprisonment.3 No athlete has yet been banned from a sport or lost endorsements because of GH, as no legally defensible test for the hormone currently exists, though the World Anti-Doping Agency (WADA) claims they are near to having an algorithm developed that can detect GH use.
Many companies have touted products that claim to increase GH by stimulating natural GH production and release. The limitation to circulating GH isn't production, as the body has stores of GH in the pituitary well in excess of what's released. Instead, an interactive network of releasing hormones, inhibitors and secretagogues regulate the endocrinological balance to prevent GH excess or deficit in healthy people.4 Athletes have learned that increasing GH levels through daily or near-daily injections promotes tissue healing, reduces body fat and may increase muscle mass. The elderly also have a strong interest in GH, as natural levels steadily decrease after age 30, a fact implicated in the age-related decline in physical and mental function.5 Thus, both groups have been following the developments, or lack thereof, of a class of drugs called GH secretagogues.
Several pharmaceutical companies, large and small, have developed GH secretagogues after it was discovered that small peptide fragments of the larger protein, growth hormone-releasing hormone (GHRH) can stimulate GH release from the pituitary.6 GHRH is a hormone produced in the hypothalamus, the gland in the brain that regulates many hormone levels. When the hypothalamus detects conditions that require the release of more GH, it releases GHRH, which travels directly to the pituitary to stimulate GH release. GHRH is too large a protein to be administered orally (meaning it can't be taken as a pill), but smaller fragments of GHRH can be effective orally. Most of the early secretagogue work revolved around fragments of GHRH.
Other stimulators of GH have been discovered, including a hormone produced by the stomach called ghrelin (pronounced gray-lin). Ghrelin interacts with a different class of pituitary receptors than GHRH, promoting GH release through a separate pathway.7 Ghrelin's name is a shortened form for GH-releasing protein. Pharmaceutical companies, including Pfizer, hastened to find novel drugs that might take advantage of the ghrelin pathways for stimulating GH release. Among these was a drug called capromorelin.8,9

An Unsuitable Candidate

Capromorelin is being referred to in the past tense, as Pfizer discontinued developing the drug in 2002 due to limited efficacy and reports of side effects that made it an unsuitable candidate for FDA approval.10 It's very difficult to obtain FDA approval for drugs designed to treat signs and symptoms of normal aging, as the FDA doesn't consider aging to be a disease and maintains very high standards for safety and efficacy.11 Other pharmaceutical powerhouses have also terminated their GH secretagogue programs, including Merck and Bristol-Myers Squibb.10,11
However, capromorelin recently made the news as one of the clinical investigators participating in a Pfizer study reported on results at the 2006 International Congress of Neuroendocrinology in Pittsburgh. Dr. George Merriam, professor of medicine at the University of Washington and a physician with the VA Puget Sound Health Care System, presented the findings of a multi-site study, which enrolled nearly 400 elderly adults between the ages of 65-84. Merriam stated that the subjects gained over 3 pounds of lean mass, improved physical function (activities like walking) and had higher GH and IGF-1 levels; side effects were minor and included fatigue, insomnia and hyperglycemia (high blood sugar).11,12
What wasn't disclosed in the media reports on this presentation was that Dr. Merriam's data was based on a study that terminated prior to 2002. The impression given most readers was that capromorelin was currently being actively developed and possibly moving toward FDA approval. A conversation with Stephen Lederer, senior director of media relations at Pfizer Global Research and Development confirmed that capromorelin was no longer being developed as of 2002, and that Dr. Merriam's data related to earlier clinical trials. Mr. Lederer noted that there was enthusiasm among some of the clinical investigators for further developing capromorelin, but that an exhaustive analysis by Pfizer deemed it an unsuitable candidate after $71 million had been spent on the project.
Needless to say, it was not a decision made lightly. Mr. Lederer provided the following quote: "We greatly respect Dr. Merriam and the other investigators we work with and value their opinions. In this case, we firmly believe the decision to discontinue was appropriate and was in the interests of patients. We saw some increase in body mass, but no significant improvement in physical function. We believed that the lack of functional improvement and the side effects we observed were unacceptable in a chronic-use medicine. Our considerable experience led us to believe that this risk/benefit ratio would not have been acceptable to regulatory agencies for the prevention of age-related declines in physical performance.13

A Growing Demographic

On a more positive note, the rights to Bristol-Myers Squibb's secretagogue program have been purchased by Elixir Pharmaceuticals, a smaller company that focuses on age-related diseases, so it's possible that future developments in this area may be announced.14 The growing demographic of aging baby boomers and the recognition of further benefits associated with preventing age-related GH decline such as improved mental performance, in addition to the physical benefits, ensure continued public interest in the field.15
Given the lack of an available secretagogue and the efficacy of GH and the natural stimulus to GH provided by exercise, why would any athlete be interested in GH secretagogues?16 Previous experiences with dietary supplements claiming to promote GH release have been variable, with many providing little apparent benefit. Amino acid-based GH releasers, though capable of inducing a greater GH release at rest, appear to actually inhibit exercise-induced GH release.17-19
Pharmaceutical GH secretagogues may offer several benefits that aren't currently available with GH. First, a number of orally active formulations have been developed. Though often short-acting, continuous-release capsules have been produced- even in the case of capromorelin. It's unclear whether a sustained, long-acting version of a secretagogue would provide any clinical benefits, as GH is released in several short bursts throughout the day rather than as a long, continuous flow. Nonetheless, injections could be avoided, reducing cost, storage problems, injection site trauma or infection, as well as any related pain or discomfort. Second, the other "regulators" of GH release would still be active in the body, reducing the risk of side effects related to GH excess. It's important to note that some side effects were still noted in Dr. Merriam's study group, but it's possible that a younger population may better tolerate the therapy. The observation of a higher risk of side effects in older subjects has been noted with testosterone therapy in men and estrogen therapy in women.20,21

The Return of Cadaveric GH

The last notable benefit relates to athletes who might abuse GH in sports doping. At this time, the International Olympic Committee (IOC) doesn't ban GH secretagogues as they're not commercially available, though expect WADA and related groups to respond more pro-actively after the revelations exposed during the BALCO scandals. While it's obvious that GH secretagogues could be used by athletes for the purpose of increasing GH, it's also possible that GH secretagogues could be used, even at this time, to foil the proposed GH-detecting algorithms suggested by WADA, allowing athletes to use the more potent and effective method of recombinant GH injections.
Here's how it might work: Currently, it's impossible to detect exogenous GH doping, as the recombinant product is identical to one form produced in the body.22,23 WADA has proposed to test athletes' blood (as opposed to urine, which is used in nearly every other test) for two different sets of markers. First, WADA would check to see if the form of GH present in commercially available products is present in greater amounts, compared to the other forms, than is naturally seen.24 This is similar to the 4:1 ratio of testosterone:epitestosterone that's used in some screens and was defeated by use of the "the cream." The cream contained both testosterone and epitestosterone, which lowered the testosterone:epitestosterone ratio back down to accepted levels, preventing a positive drug test.[Author's note- the ratio of testosterone to epitestosterone is the doping detection screen that prompted the allegations of testosterone use by 2006 Tour de France champion Floyd Landis].25
GH secretagogues could stimulate the release of natural GH, including all the isoforms tested for by the proposed WADA plan, restoring isoform ratios back to accepted levels. Of course, this would have to be titrated individually with each athlete, making it expensive, unless they were willing to chance it on a general program. This assumes that illicit manufacturers aren't providing GH products that include a natural combination of the various isoforms. One deadly risk that WADA may actually be propagating is the return of cadaveric GH.
Prior to the discovery of a method of producing GH via recombinant methods (meaning in a laboratory), GH was obtained by extracting it from the pituitary of dead people. This now-banned source, while once valuable to children being treated with the extract, exposed them and doping athletes to the risk of contracting a deadly disease called Creutzfeldt-Jakob disease, similar to mad cow disease.26,27 There's been at least one case of a French bodybuilder contracting Creutzfeldt-Jakob, possibly from cow-derived, cadaveric GH extract or tainted meat imported from Great Britain (England had an epidemic of mad cow disease at the time) or sporadically- as others of that era caught the disease.28,29 The French bodybuilder died at the age of 26.
The second leg of the GH-detection algorithm wouldn't be circumvented, as it looks for markers of GH action to determine if supraphysiologic GH levels existed in an individual athlete, such as insulin-like growth factor-1 (IGF-1) and type III procollagen (P-III-P).30 Considering that most athletes are healthy, active and young, it's likely that the threshold will have to be set fairly high. This would limit the total benefit that could be attained through GH and GH secretagogue use, though the window of opportunity would be greater for older athletes. Many athletes are extending their careers into their late 30s and early 40s, making this more relevant with each passing year.

Offering Great Promise to the Aging & Athletic

This article doesn't advocate the use of GH or GH secretagogues for doping purposes. Instead, it's a response to reports of archived data that has raised the hopes of those facing declining function due to aging, or those hoping for a safer and more convenient means of promoting optimal GH to improve appearance and performance. It also raises a prospective inquiry regarding attempts by doping athletes to violate the ethics and rules of organized sports.
GH therapy offers great promise to the aging and athletic. Secretagogues, such as capromorelin, may provide a bridging therapy to those who either choose to avoid GH injections, or seek less expensive alternatives. At this time, there's no pharmaceutical secretagogue commercially available, and it remains to be seen if any of these oral drugs will provide similar effects to GH over the long-term. Further, it will be interesting to see if protocols will be developed allowing those first experiencing signs and symptoms of GH decline in their 30s and 40s to access either GH or GH secretagogues. As has been suggested with research involving the hormones testosterone and estrogen, introducing the therapy early, rather than waiting until frailties manifest, may reduce risks. As the first of the baby boomers enter their 60s, perhaps this politically affluent generation will prompt changes in legal and professional restrictions.

References:
  • 1. Morley JE, Unterman TG. Hormonal fountains of youth. J Lab Clin Med, 2000;135:364-6.
  • 2. Llewellyn W. Human Growth Hormone (somatotropin). Anabolics 2005. Body of Science Press, Jupiter, FL;2005:288-90.
  • 3. Brundett R. Shortt gets jail; players not off hook. The State [South Carolina], 2006 July 18.
  • 4. Surya S, Symons K, et al. Complex rhymicity of growth hormone secretion in humans. Pituitary, 2006 Jul 15;[Epub ahead of print].
  • 5. Mooradian AD, Morley JE, et al. Endocrinology in aging. Dis Mon, 1988;34:393-461.
  • 6. No Author Listed. Pralmorelin: GHRP 2, GPA 748, growth hormone-releasing peptide 2, KP-102 D, KP-102 LN, KP-102D, KP-102LN. Drugs, R D 2004;5:236-9.
  • 7. Kojima M, Hosoda H, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature,1999;402:656-60.
  • 8. Carpino PA, Lefker BA, et al. Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs). Discovery of capromorelin. Bioorg Med Chem, 2003;11:581-90.
  • 9. Carpino PA, Lefker BA, et al. Discovery and biological characterization of capromorelin analogues with extended half-lives. Bioorg Med Chem Lett, 2002;12:3279-82.
  • 10. Cohen F. Quest for youth: How research on anti-aging pill lost momentum. Available at http://blog.crownstoneinsights.com/notes/archive/2006_07_01_archive.html, accessed July 28, 2006.
  • 11. Fox M. Drug, blood provide clues to healthy aging-meeting. Reuters News Service, 2006 Jun 21.
  • 12. Reedy J. Growth hormone stimulators improve physical function in older adults. Public Release - University of Washington, via EurekAlert! news service.
  • 13. Lederer S. Personal communication via phone and email, July 25, 2006.
  • 14. Elixir Pharmaceuticals. Elixir Pharmaceuticals licenses novel growth hormone secretagogue compound from Bristol-Myers Squibb for treatment of metabolic disorders. 2005 Apr 28. Press Release available at http://www.elixirpharm.com/company/pr/squibb_050205.pdf, accessed July 28, 2006.
  • 15. Arwert LI, Veltman DJ, et al. Memory performance and the growth hormone/insulin-like growth factor axis in the elderly: a positron emission tomography study. Neuroendocrinology, 2005;81:31-40.
  • 16. Weltman A, Weltman JY, et al. Growth hormone response to graded exercise intensities is attenuated and the gender difference abolished in older adults. J Appl Physiol, 2006;100:1623-9.
  • 17. Marcell TJ, Taaffe DR, et al. Oral arginine does not stimulate basal or augment exercise-induced GH secretion in either young or old adults. J Gerontology, 1999;54A:M395-399.
  • 18. Surninski RR, Robertson RJ, et al. Acute effect of amino acid ingestion and resistance exercise on plasma growth hormone concentration in young men. Int J Sport Nutr, 1997;7:48-60.
  • 19. Besset A, Bonardet A, et al. Increase in sleep related GH and Prl secretion after chronic arginine aspartate administration in man. Acta Endocrinol (Copenh), 1982;99:18-23.
  • 20. Bhasin S, Woodhouse L, et al. Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle. J Clin Endocrinol Metab, 2005;90:678-88.
  • 21. Naftolin F. Prevention during menopause is critical for good health: skin studies support protracted hormone therapy. Fertil Steril, 2005;84:293-4.
  • 22. McHugh CM, Park RT, et al. Challenges in detecting the abuse of growth hormone in sport. Clin Chem,2005;51:1587-93.
  • 23. Rigamonti AE, Cella SG, et al. Growth hormone abuse: methods of detection. Trends Endocrinol Metab,2005;16:160-6.
  • 24. Project Review. Transition from research lab to ISO-certified optimization and production of differential immunoassays for the detection of GH-doping in sports based on the isoform approach. World Anti-Doping Agency. Available at http://www.wada-ama.org/rtecontent/document/DrSoehnge.pdf, accessed July 28, 2006.
  • 25. Mann D. Innocent reasons for Landis dope test? WebMD Medical News 2006 July 27. Available at http://www.webmd.com/content/article/125/116062, accessed July 28, 2006.
  • 26. Brown P, Gajdusek DC, et al. Potential epidemic of Creutzfeldt-Jakob disease from human growth hormone therapy. N Engl J Med, 1985;313:728-731.
  • 27. Deyssig R, Frisch H. Self-administration of cadaveric growth hormone to power athletes. Lancet, 1993;341:768-769.
  • 28. Chazot G, Broussole E, et al. New variant of Creutzfeldt-Jakob in a 26-year-old French Man. Lancet, 1996;347:1181.
  • 29. Verdrager J. New variant Creutzfeldt-Jakob disease and bovine pituitary growth hormone. Lancet, 1998;351:112-3.
  • 30. Sonksen & Holt. The development of methodology for detecting growth hormone in sport:GH2004. World Anti-Doping Agency. Available at http://www.wada-ama.org/rtecontent/document/A1_2002_results.pdf, accessed July 28, 2006.

50 Rules Of Fat-Burning: Simplyshredded.com Collects The Strongest Clinical Research From Around The World

50 Rules Of Fat-Burning: Simplyshredded.com Collects The Strongest Clinical Research From Around The World

Whatever your doing must not be working. Why else would you be reading this?
You swapped fried chicken for grilled and your treadmill is finally getting more attention than your TiVo. But your body isn’t quite where you want it to be. Don’t worry: Your bag of fat-burning tricks isn’t empty yet. We’ve collected 50 comprehensive tips, all backed by more science than a NASA shuttle launch. By the time you’ve incorporated these fat-burning gems, we’ll have 50 more for you. But by then, you probably won’t need them.

What You Eat

Getting lean obviously relies heavily on a solid nutrition plan. So it should come as no surprise that what and how you eat can have a big impact on your success. Use these 11 food rules to amp up your fat-burning potential.

1. Go Pro

A high-protein diet not only promotes hypertrophy but also enhances fat loss. Researchers at Skidmore College (Saratoga Springs, New York) found that when subjects followed a high-protein diet–40% of total daily calories from protein–for eight weeks, they lost significantly more bodyfat, particularly abdominal fat, than those following a low-fat/high-carb diet. One reason eating more protein may work is that it boosts levels of peptide YY, a hormone produced by gut cells that travels to the brain to decrease hunger and increase satiety.

2. Slow Down

When you reach for carbs, choose slow-digesting whole grains such as brown rice, oatmeal and whole-wheat bread, which keep insulin levels low and steady, and prevent insulin spikes from halting fat-burning and ramping up fat-storing.
A study conducted by researchers at Pennsylvania State University (University Park) found that subjects following a low-calorie diet with carbs coming only from whole grains lost significantly more abdominal fat than those following a low-calorie diet with carbs from refined sources.

3. Get Fat

Not only will certain fats–particularly omega-3s –not lead to fat gain, but they can actually promote fat loss. Eating fat to lose fat seems counterintuitive, but if you keep your fat intake at about 30% of your total daily calories by choosing fatty fish such as salmon, sardines or trout as well as other healthy fat sources such as olive oil, peanut butter and walnuts, you can actually boost your fat loss compared to eating a low-fat diet.

4. Egg You On

Eggs are packed with protein and have been shown to promote muscle strength and mass, and research shows that subjects consuming eggs for breakfast not only eat fewer calories throughout the day but also lose significantly more bodyfat. We recommend eating eggs for breakfast daily, scrambling three whole eggs with three egg whites.

5. Unforbidden Fruit

A study from the Scripps Clinic (San Diego) reported that subjects eating half a grapefruit or drinking 8 ounces of grapefruit juice three times a day while otherwise eating normally lost an average of 4 pounds in 12 weeks, with some test subjects losing more than 10 pounds without dieting. The researchers suggest the effect is likely due to grapefruit’s ability to reduce insulin levels. Try adding half a grapefruit to a few of your meals such as breakfast, lunch and preworkout.

6. Milk It

Dairy products are rich in calcium, which can help spur fat loss, particularly around your abs. This may be due to the fact that calcium regulates the hormone calcitriol, which causes the body to produce fat and inhibit fat-burning. When calcium levels are adequate, calcitriol and fat production are suppressed while fat-burning is enhanced. Adding low-fat versions of cottage cheese, milk and yogurt (Greek or plain) to your diet are great ways to boost protein intake and aid fat loss.

7. An Apple A Day

Apples are a great slow-digesting carb that contain numerous beneficial antioxidants. One group of compounds known as apple polyphenols has been found to boost muscle strength, endurance and even fat loss, especially from around the abs.  While apple polyphenols appear to directly decrease bodyfat by increasing the activity of genes that enhance fat-burning and decrease fat production and storage, the boost in endurance and strength can help further fat loss by allowing you to train harder longer.
A typical large apple provides about 200 mg of apple polyphenols and about 30 grams of carbs.

8. Spice It Up

Hot peppers contain the active ingredient capsaicin, a chemical that has been shown to promote calorie-burning at rest as well as reduce hunger and food intake. Its effects are particularly enhanced when used with caffeine, and research also shows that it boosts fat-burning during exercise. Try adding crushed red pepper, hot peppers or hot pepper sauce to your meals to burn extra calories and fat. If you can’t stand the heat, try supplements that contain capsaicin.

9. Go Nuts

A study from Loma Linda University (California) reported that subjects following a low-calorie, higher-fat diet (40% of total calories from fat) with the majority of fat coming from almonds lost significantly more bodyfat and fat around the abs in 24 weeks than subjects consuming the same calories but more carbs and less fat. So be sure to include nuts such as almonds, Brazil nuts, macadamia nuts and walnuts in your diet.

10. Be Multi-Organic

Sure, it’s pricier, but organic beef and dairy are worth the extra bucks. UK scientists found that organic milk had about 70% more omega-3 fatty acids than conventional milk, and a study published in the Journal of Dairy Science found that grass-fed cows produced milk containing 500% more conjugated linoleic acid [CLA) than cows who ate grain. Meat from organically raised cattle also contains higher levels of CLA and omega-3 fats. Since omega-3s and CLA can help you drop fat as well as gain muscle, it makes sense to shell out the extra cash for organic cheese, cottage cheese, milk and yogurt as well as grass-fed beef.

11. Add Some GUAC

Avocados are full of monounsaturated fat, which isn’t generally stored as bodyfat. They also contain mannoheptulose, a sugar that actually blunts insulin release and enhances calcium absorption.
As mentioned earlier, keeping insulin low at most times of day is critical for encouraging fat loss, and getting adequate calcium can also promote fat loss. Try adding a quarter of an avocado to salads and sandwiches.

What You Drink

Beverages can play an important role in your ability to drop fat. Consider sipping or passing on these eight beverages to get extra-lean.

12. Go Green

The main ingredient in green tea, epigallocatechin gallate (EGCG), inhibits the enzyme that normally breaks down the neurohormone norepinephrine.  Norepinephrine keeps the metabolic rate up, so preventing its breakdown helps you burn more calories throughout the day. Drinking green tea is a great way to stay hydrated during workouts, as a new study in The Journal of Nutrition reported that subjects drinking green tea and exercising lost significantly more abdominal fat than those drinking a placebo.

13. In The Black

Green, oolong and black teas all come from the same plant, but different processing causes black and oolong teas to lose their green color and turn brownish/black. Oolong tea has been shown to enhance metabolic rate due to polyphenols other than EGCG.  Black tea may also aid fat loss: Researchers from University College London reported that black tea consumption can help reduce Cortisol levels, which encourages fat storage especially around the midsection.

14. Be Aqua Man

German researchers have shown that drinking about 2 cups of cold water can temporarily boost metabolic rate by roughly 30%. The effect appears to be mainly due to an increase in norepinephrine.

15. Get Energized

Certain energy drinks have been shown to boost fat loss. University of Oklahoma (Norman) researchers reported in a 2008 study that when 60 male and female subjects consumed a diet energy drink containing 200 mg of caffeine and 250 mg of EGCG from green tea extract for 28 days, they lost more than 1 pound of bodyfat without changing their diets or exercise habits.

16. Whey Lean

Drinking whey protein as a between-meals snack is a smart way to enhance not only muscle growth but also fat loss. UK researchers found that when subjects consumed a whey protein shake 90 minutes before eating a buffet-style meal, they ate significantly less food than when they consumed a casein shake beforehand. The scientists reported that this was due to whey’s ability to boost levels of the hunger-blunting hormones cholecystokinin and glucagonlike peptide-I.

17. Say Soy-Anara To Fat

Soy protein is a proven fat-burner. In fact, in a 2008 review paper University of Alabama at Birmingham researchers concluded that soy protein can aid fat loss, possibly by decreasing appetite and calorie intake. The scientists also found that subjects drinking 20 grams of soy daily for three months lost a significant amount of abdominal fat.

18. Get Thick

When you whip up a protein shake, consider making it thicker by using less water. It could help you feel less hungry while dieting. In a study from Purdue University (West Lafayette, Indiana), subjects drank two shakes that were identical in nutritional content, and reported significantly greater and more prolonged reductions in hunger after drinking the thicker shake.

19. Not So Sweet

Even though artificially sweetened drinks are calorie-free, drinking too many can actually hinder your fat-loss progress. It seems that beverages like diet soda mess with your brain’s ability to regulate calorie intake, causing you to feel hungrier than normal so you eat more total calories.
Other research suggests that the sweet taste of these drinks can increase the release of insulin, which can blunt fat-burning and enhance fat storage.

What Supplements You Take

While whole foods are the key element to getting lean, supplements can provide a potent fat-burning stimulus. Consider using these six supps.

20. Go Even Greener

The majority of studies showing the effectiveness of green tea for fat loss have used green tea extract. One study confirmed that the EGCG from the extract was absorbed significantly better than the EGCG from the tea. Take about 500 mg of green tea extract in the morning and afternoon before meals.

21. See CLA

You’ll also want to add the healthy fat CLA to your supplement regimen. CLA can significantly aid fat loss while simultaneously enhancing hypertrophy and strength gains. Research shows it can even help specifically target ab fat.

22. Go Fish

As mentioned in tip No. 3, the essential omega-3 fats in fish oil promote fat loss, which is enhanced with exercise. This is also true for fish-oil supplements containing omega-3 fats. Take 1-2 grams of fish oil at breakfast, lunch and dinner.

23. You Bet Your Astaxanthin

Japanese researchers reported in a 2008 study that mice supplemented with astaxanthin combined with an exercise program for four weeks saw accelerated fat-burning, greater fat loss and enhanced endurance compared to mice that just exercised. The scientists determined that astaxanthin protects the system that transports fat into the mitochondria of muscle cells where it’s burned as fuel. Take 4 mg of astaxanthin with food once or twice per day, with one dose taken with your preworkout meal.

24. Go Commercial

A 2009 study reported that lifters taking the fat-burner Meltdown by VPX (containing caffeine, synephrine, yohimbine and beta-phenylethyl-amine, to name a few) burned 30% more calories and had a more than 40% increase in markers of lipolysis (fat release from fat cells) for the 90 minutes afterward when researchers measured calorie burn compared to when subjects consumed a placebo. Regardless of the brand of thermogenic you choose, follow label instructions and take the other five supplements mentioned here as well.

How You Lift

The way you weight-train can have a huge effect on how much fat you burn. Consider these eight rules when hitting the iron.

25. Carry More Fat Away With Carnitine

This amino-acidlike compound is critical for carrying fat in the body to the mitochondria of cells, where it’s burned away for good. Research confirms that taking carnitine when dieting can help maximize fat-burning efforts. Take 1-2 grams of carnitine in the form of L-carnitine, L-carnitine L-tartrate or glycine propionyl-L-carnitine.

26. Go Heavy

Excess post-exercise oxygen consumption refers to the increased metabolic rate you enjoy after a workout. Scien- tists at the Norwegian University of Sport and Physical Education (Oslo) analyzed multiple studies and found that training with heavier weights for fewer reps produces a greater rise in resting metabolic rate that’ll last longer compared to training with lighter weights and doing more reps. Although most guys may think they need to train with higher reps to burn more fat, you still want to lift heavy (3-7 reps) some of the time to maximize the calories and fat you burn when you’re not at the gym.

27. Go Light

While lifting heavy does burn more calories post- workout, performing higher reps burns more calories during the workout, as College of New Jersey (Ewing) researchers reported at a 2007 annual meeting of the National Strength and Conditioning Association.(51) Be sure to mix up your training by using lighter weight and higher reps (10-20) during some workouts and heavy weight and low reps (3-7) in others. Another way to get the best of both worlds is to perform four sets of most exercises, doing your first two sets with heavy weight and low reps and the last two with light weight and high reps.

28. Rest Less

Researchers from the College of New Jersey (Ewing) also discovered that when subjects rested 30 seconds between sets on the bench press, they burned just more than 50% more calories than when they rested three minutes.
To maximize fat toss, keep your workout moving by resting less than a minute between sets.

29. Force It

A study on collegiate football players found that using a high-intensity weight program–just one set per exercise for 6-10 reps to failure, plus forced reps and a static contraction for several seconds–caused more bodyfat loss in 10 weeks than a lower-intensity program consisting of three sets of 6-10 reps per exercise taken just to muscle failure. This could be due to a greater hike in growth hormone (GH) in the high-intensity group: In a study from Finland, forced reps boosted GH three times higher than training to failure. Go past failure when trying to get lean by using forced reps, static contractions, rest-pause or drop sets.

30. Be Free

Using free weights, especially in multijoint moves such as the squat, has been found to burn more calories than doing similar exercises on machines like the leg press. Scientists said the difference may be due to the greater number of stabilizer muscles used during multijoint exercises done with free weights.

31. Feel The Need For Speed

Fast, explosive reps burn more calories than the typical slow, controlled reps you’re used to doing in the gym, say researchers from Ball State University (Muncie, Indiana). They believe that because fast-twitch muscle fibers are less energy-efficient than their slow-twitch counterparts, they burn more fuel during exercise. To perform fast reps in your workouts, choose a weight equal to 30`% of your one-rep max (or a weight you can lift for 15-35 reps) for each exercise. Do your first two sets with 3-8 fast reps, then follow with 2-3 sets of normal-paced reps.

32. Be Negative

In one recent study, subjects who performed a negative-rep workout of three sets of the bench press and squat increased their GH levels by almost 4,000%. Since GH frees up fat from fat cells, using negative reps may help you shed extra bodyfat. To add negatives to your routine, either have a spotter help you get 3-5 negative reps after reaching failure on a regular set, or load the bar with about 120% of your one-rep max and have a spotter help you perform five negative reps that take you 3-5 seconds each to complete.

33. Tune In

Listening to your iPod can boost your workout intensity and fat-loss efforts. A study conducted by the Weider Research Group and presented at the 2008 annual meeting of the National Strength and Conditioning Association found that trained subjects listening to their own music selection could complete significantly more reps than when they trained without their preferred music.

How You Run

Cardio, obviously, is a primary component of getting lean. It’s the easiest way to burn the most calories during exercise. Use these eight rules to help you maximize your fat loss.

34. Go After It

Do your cardio after you hit the weights. Japanese researchers found that when subjects performed cardio after resistance training, they burned significantly more fat than when they did cardio first. The scientists also reported that fat-burning was maximal during the first 15 minutes of cardio following the weight workout, so hit the stationary bike, elliptical machine or treadmill after you lift, even if it’s for just 15 minutes.

35. Hiit It

The best way to burn the most fat with cardio is via high-intensity interval training (HIIT). This involves doing intervals of high-intensity exercise (such as running at 90% of your max heart rate) followed by intervals of low-intensity exercise (walking at a moderate pace) or rest. A litany of research confirms that this burns more fat than the continuous, steady-state cardio most people do at a moderate intensity, such as walking for 30 minutes at 60%-70% of their max heart rates.

36. Stagger It

In one study, subjects who did three 10-minute bouts of running separated by 20-minute rest periods found the workout easier than when they ran at the same intensity for 30 minutes. The intermittent cardio even burned more fat, and has also been shown to burn more calories postworkout than the same amount of continuous exercise.

37. Fashionably Late

The time of day you do your cardio can impact how many calories you burn post-workout. University of Wisconsin, La Crosse, researchers reported that endurance-trained subjects who performed 30 minutes of stationary cycling between 5 p.m. and 7 p.m. raised their metabolic rates higher postworkout than when they did the same cardio exercise between 5 a.m. and 7 a.m. or between 11 a.m. and 1 p.m. While your best bet is to train whenever it best fits your schedule, try training in the evening to enhance your postworkout calorie burn.

38. Be Scottish

University of Edinburgh (Scotland) researchers reported that when subjects did 4-6 30-second sprints on a stationary cycle separated by four minutes of rest for just two weeks, their blood-glucose and insulin levels were reduced by almost 15% and 40%, respectively, and insulin sensitivity improved by about 25%, following consumption of 75 grams of glucose. Keeping insulin levels low and steady can help maximize fat-burning and minimize fat storage.
So even if you don’t have 20-30 minutes for a cardio workout, doing just 2-3 minutes of sprinting can at least help keep insulin down and fat-burning up.

39. Climb It

Consider other forms of cardio. A recent study from Italy found that when subjects rock-climbed, their average heart rates were about 80% of their max, which equates to a pretty intense cardio session. In addition, subjects burned about 12 calories per minute for a 180-pound guy, or just less than 400 calories in 30 minutes. Check out indoor or outdoor rock-climbing sites in your area.

40. Kick It

Another way to get your cardio is with martial arts. Wayne State College (Nebraska) researchers found that when beginning martial artists performed a tae kwon do workout of cycling between front kicks, butterfly stretches, forearm strikes, crunches, side kicks, quad stretches and push-ups, their heart rates rose 80% and they burned about 300 calories per half-hour. Besides tae kwon do, you can try aikido, jiu-jitsu, judo, karate, kung fu or any other style of martial arts.

41. Spit It Out

University of Birmingham (Edgbaston, UK) scientists found that when trained cyclists rode as fast as possible while rinsing their mouths with a beverage similar to a sports drink and spitting it out every 7-8 minutes, they could cover a certain mileage three minutes faster than when they rinsed with water. We don’t suggest you try this in an indoor cycling class, but rinsing your mouth every 10 minutes with a sports drink and spitting it out could help you train at a higher intensity–without the added calories.

Other Rules

Some things that can impact your ability to lose fat may not be directly related to what you eat or drink, or to your exercise routine. Still, these nine tips could aid fat loss.

42. Get Up

Research from Australia found that out of 2,000-plus subjects who exercised vigorously for at least 2.5 hours per week, those who watched more than 40 minutes of television per day had higher waist circumferences than those watching less than 40 minutes. The scientists theorize that sitting for prolonged periods compromises the body’s ability to burn fat, which was shown by University of Missouri-Columbia researchers in both animals and humans. Avoid this slump by getting up and stretching at least every 20 minutes while sitting at work or at home.

43. Take A Picture

A picture could be worth a thousand calo- ries. Researchers from the University of Wisconsin-Madison found that test subjects who recorded with photographs what they ate for one week reported that the images triggered critical evaluation of the food before eating it, prompting them to make better food choices. This wasn’t the case for subjects who simply wrote down what they ate. Try keeping a photo food log as well as a journal in which you calculate your macronutrient intake.

44. Portion It

One study from Cornell University (Ithaca, New York) reported that when moviegoers were given a large acontainer (about 22 cups)of fresh popcorn during a movie, they ate 45% more than those given a medium container (about II cups). Even more disturbing was that subjects given a large container of stale popcorn still ate about 35% more than those given a medium container, even though they rated the popcorn’s taste as bad.
You can use this research in a couple of ways: For lean protein sources, give yourself a large amount; for side dishes such as rice, potatoes and bread, keep the serving on the small side.

45. Laugh It Off

Japanese scientists found that when subjects ate a 500-calorie meal while watching a 40-minute comedy show, their blood-glucose levels were much lower than when they consumed the same meal during a boring 40-minute lecture. The researchers suggest that laughter may have altered subjects’ brain chemistry in such a way that glucose entered the blood more slowly, or blood glucose was taken up by the muscles more rapidly. Try eating meals while watching something funny on TV to keep your blood-glucose and insulin levels low to help encourage fat loss.

46. Sleep On It

One study in the American Journal of Epidemiology reported that subjects sleeping five hours or less per night were one-third more likely to gain 30-plus pounds over the 16-year study than those who slept seven hours or longer per night. This may be due to an imbalance in the hormones leptin and ghrelin: While leptin decreases hunger and increases the metabolic rate, ghrelin boosts hunger. A study by University of Chicago researchers found that men who were sleep-deprived for two days experienced a rise in ghrelin levels and a drop in leptin levels, along with a concomitant rise in hunger. A Stanford University (California) study showed that subjects who slept the least had lower levels of leptin and higher levels of ghrelin and bodyfat compared to those who slept eight hours.
Try to get 7-9 hours of sleep every night to not only enhance your recovery but also aid your health and help you keep fat off.

47. Chew It

A study done at Glasgow Caledonian University (Scotland) found that subjects who chewed gum between meals ate significantly less food at the second meal than those who didn’t chew gum. The researchers concluded that chewing gum increases satiety and therefore reduces food intake.

48. Be A Transporter

Remember, any activity you do burns calories, and burning more calories than you consume is the most critical aspect of getting lean. So consider how far away certain destinations are such as work, the gym, the grocery store and your friends’ homes. Depending on the distance and the time you have, walk or bike to burn more calories and fat.

49. Feel The Vibe

In a study from Stony Brook University (New York), mice placed on a vibrating platform for 15 minutes a day for up to 15 weeks were found to have less bodyfat than mice not exposed to vibration. Research in humans has seen similar results with vibration exposure enhancing fat loss. If your gym has a vibration machine–often called a Power Plate–get a trainer to walk you through it and consider using it for a few minutes a couple of times per week.

50. Be A Gamer

The popular and very active video game Dance Dance Revolution can provide a great workout, according to researchers from the University of Wisconsin, La Crosse.
They reported that adult subjects burned as man